Victoza®

GLP-1, liraglutide, injection

Victoza® mimics a gut hormone called glucagon-like peptide-1 (GLP-1). When you eat, GLP-1 is released in your gut, slowing digestion and helping you feel full. It also:

Reduces appetite

Regulates insulin

Balances blood sugar

Everything you need to know about
Victoza®

What is
Victoza®
?

Victoza, a brand name for liraglutide, is manufactured by Novo Nordisk. It is a synthetic version of the GLP-1 hormone.

The U.S. Food and Drug Administration (FDA) approved Victoza to treat type 2 diabetes. It lowers blood sugar levels and reduces the risk of major cardiovascular (CV) events like stroke, heart attack, or death in adults with type 2 diabetes with known heart disease. (Victoza is not prescribed for treating type 1 diabetes.) Clinicians prescribe it off-label for weight loss because clinical evidence shows it also helps people lose weight.

More on off-label prescribing

There is currently no FDA-approved generic version of Victoza.  

Benefits of
Victoza®

Expected weight loss depends on whether Victoza is taken alone or with metformin and if you have medical conditions like type 2 diabetes. According to Novo Nordisk, in clinical studies ranging from 26 to 52 weeks, many adults with type 2 diabetes who took Victoza lost some weight. In one large study, when participants took Victoza with metformin, they lost, on average, up to 6.2 lb. (Safe weight loss is one to two pounds per week.)

Victoza may have more benefits than just treating type 2 diabetes and weight management. Victoza lowered the risk of death from heart and blood vessel diseases by 22% in the LEADER clinical trial. The same study also found a 22% risk reduction of kidney disease, and a 31% risk reduction of severe hypoglycemia (low blood sugar) in patients with longstanding type 2 diabetes and a risk for heart disease.

How does
Victoza®
work?

When you eat, it stimulates the release of the GLP-1 hormone in your gut. GLP-1 helps lower blood glucose (blood sugar) by triggering insulin release. Insulin helps blood glucose enter your body’s cells for later energy use. 

In some people, the gut doesn't make enough natural GLP-1, or the brain isn't sensitive to it. 

Victoza is a synthetic GLP-1 receptor agonist. It works in the gut like natural GLP-1 by activating the same cell receptors as the body's hormones. Because Victoza slows digestion, it helps curb hunger and signal fullness to the brain. As a result, some people with obesity have lost weight while taking it.

Because Victoza supports a process the body isn’t doing well, it may require long-term use

It’s important to note that GLP-1 medications don’t work for everyone. There are dozens of biological reasons why people struggle to lose weight. Found’s clinicians, trained in obesity medicine, can help patients identify the root cause of their weight gain and personalize a prescription to target it. All prescriptions are up to a medical provider’s discretion.

More on personalized treatment with Found

How to use it

Take Victoza as instructed by a qualified health care provider. Novo Nordisk recommends injecting Victoza once a day under the skin in your upper arm, upper thigh, or stomach. Do not use the same site for each injection. Store your Victoza pen, with the cap on, in the refrigerator.

Dosing

For most patients, dosing begins with 0.6 mg once-daily injections for one week and increases to 1.2 mg daily if medically indicated for further blood sugar control and if you tolerate it. After a week, if additional glycemic control is needed, your provider may increase your daily dose to a maximum of 1.8 mg.

Side effects

Rapid or significant weight loss can lead to too much muscle loss. It’s important to start a strength training program and exercise regularly to protect your muscles while taking Victoza. 

Tell your health care provider if you have severe stomach problems that won’t go away, including abdominal bloating or pain, acid reflux, a feeling of fullness after eating just a few bites of food, nausea, and vomiting, including vomiting undigested food eaten a few hours earlier. These may be symptoms of gastroparesis (stomach paralysis).  

Use effective birth control while taking this medication. If you are pregnant, breastfeeding, or planning to become pregnant, do not take Victoza.

The FDA also warns not to take Victoza if you have a personal or family history of multiple endocrine neoplasia syndrome type 2, medullary thyroid cancer, insulin-dependent diabetes, or diabetic ketoacidosis. So, if that’s you, Victoza isn’t the right fit.

Black Box Warning

Although rare, liraglutide caused thyroid C-cell tumors in animal studies. Victoza’s “black box” warns of the risk of these tumors. If you have trouble swallowing, develop hoarseness, or feel swelling or a lump in your neck, contact your health care provider immediately.

Precautions

Rapid or significant weight loss can lead to too much muscle loss. It’s important to start a strength training program and exercise regularly to protect your muscles while taking Victoza. 

Tell your health care provider if you have severe stomach problems that won’t go away, including abdominal bloating or pain, acid reflux, a feeling of fullness after eating just a few bites of food, nausea, and vomiting, including vomiting undigested food eaten a few hours earlier. These may be symptoms of gastroparesis (stomach paralysis).  

Use effective birth control while taking this medication. If you are pregnant, breastfeeding, or planning to become pregnant, do not take Victoza.

The FDA also warns not to take Victoza if you have a personal or family history of multiple endocrine neoplasia syndrome type 2, medullary thyroid cancer, insulin-dependent diabetes, or diabetic ketoacidosis. So, if that’s you, Victoza isn’t the right fit.

Interactions

Some drugs can also interact with Victoza, including:

  • Insulin
  • Sulfonylureas (these can cause blood sugar levels to drop dangerously low when combined with Victoza) 
  • Some birth control pills
  • Other GLP-1 or GLP-1/GIP receptor agonist medications such as dulaglutide, semaglutide, or tirzepatide 

You should not drink alcohol while taking this drug because drinking can lower blood sugar. Combining alcohol with this medication may cause blood sugars to fall too fast, leading to fainting and dizziness.

about
found

Found is an online weight loss program offering personalized care for every member. Some of the nation’s top obesity medicine specialists helped design our program. Our approach is based on science, and we’re committed to clinical excellence.

Members get access to: Clinicians trained in obesity medicine 1:1 health coaching Self-paced lifestyle change program designed by doctors, psychologists, and behavioral scientists Exclusive in-app community.

Found’s comprehensive program is designed to work with your body—so you can achieve lasting results and enjoy better health.

Alternative medications

Depending on your health history, weight history, and MetabolicPrintTM assessment, your Found health care provider may consider other alternatives to help you lose weight. Some are FDA-approved for weight loss. Others are used off-label and have strong clinical evidence supporting their use for weight loss.

Unfortunately, there are no generic versions of Ozempic currently on the market.
However, your health care provider might consider alternatives such as Wegovy, Mounjaro, or Saxenda, all of which are GLP-1 medications but not all are FDA-approved for weight loss specifically.

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