Semaglutide Dissolving Tablets for Weight Loss

semaglutide, GLP-1, oral

Oral compounded semaglutide dissolving tablets mimic the glucagon-like peptide-1 (GLP-1) gut hormone. When you eat, GLP-1 slows digestion and helps you feel full. It also:

Balances blood sugar

Reduces appetite

Regulates insulin

Everything you need to know about
Oral Semaglutide Dissolving Tablets

What
is
are
Oral Semaglutide Dissolving Tablets
?

Semaglutide mimics the gut hormone GLP-1. When blood sugar levels increase after a meal, GLP-1 helps the pancreas release the right amount of insulin and slows how quickly the food moves through the digestive system.

Semaglutide is the active ingredient in popular medications like Ozempic®, Wegovy®, and Rybelsus®, manufactured by Novo Nordisk. Ozempic and Wegovy are injections, and Rybelsus is a pill that you swallow. 

These name brands of semaglutide are approved by the U.S. Food and Drug Administration (FDA) for chronic type 2 diabetes, weight management, and/or reducing major heart events in adults with cardiovascular disease. 

Compounded semaglutide oral dissolving tablets have the same active ingredient as brand-name semaglutide, but they are manufactured in compounding pharmacies. They are not FDA approved for safety or efficacy. 

Compounded semaglutide oral dissolving tablets are designed to dissolve quickly so the medicine is absorbed directly into the bloodstream through the soft tissue under the tongue or between the cheek and gum. They aren’t meant to be swallowed, and no water is necessary when you take them.

Compounded semaglutide oral dissolving tablets from Found:

  • are dosed differently than brand-name semaglutide; 
  • include other ingredients such as vitamin B6; 
  • and aren’t subject to FDA approval. (Compounded semaglutide is produced in state-licensed compounding pharmacies or FDA regulated registered outsourcing facilities that must comply with the Federal Food, Drug, and Cosmetic Act regulations or state board of pharmacy regulations)

Currently, there is no generic version of semaglutide that has been approved by the FDA.

Benefits of
Oral Semaglutide Dissolving Tablets

Expected weight loss for brand-name semaglutide pills depends on the dosage and can vary by individual. In one trial, people who took 25 mg of an oral semaglutide every day for 64 weeks lost an average of 13.6% of their total body weight. (Safe weight loss is one to two pounds per week.) 

These studies are of brand-name (not compounded) semaglutide and there are no published studies demonstrating the efficacy of compounded formulations. Most published studies about oral semaglutide involve pills that are swallowed with water, not oral dissolving tablets.

Semaglutide improves heart health by lowering blood sugar and helping people lose excess weight. Multiple clinical trials funded by Novo Nordisk show semaglutide can reduce the risk of major cardiovascular events such as heart attack, stroke, or death in adults with type 2 diabetes and known heart disease. 

Another study showed semaglutide has similar benefits in adults with obesity who do not have type 2 diabetes.

It’s significant to note that some patients have reported reduced cravings and “food noise” while using semaglutide for weight loss. 

How
does
do
Oral Semaglutide Dissolving Tablets
work?

When you eat, food stimulates the release of a hormone called GLP-1 in your gut. GLP-1 helps lower blood glucose (blood sugar) by triggering insulin release. Insulin helps blood glucose enter your body’s cells for later energy use. 

In some people, the gut doesn't make enough natural GLP-1, or the brain isn't sensitive to it. 

Semaglutide is a synthetic GLP-1 RA (receptor agonist). A drug that works as a receptor agonist activates the same cells as the body’s natural hormones. So, semaglutide works in the gut like the body’s natural GLP-1. Because semaglutide slows digestion, it helps curb hunger and signal fullness to the brain. As a result, some people with obesity have lost weight while taking it.

Because semaglutide supports a process the body can’t do well on its own, it may require long-term use

It’s important to note that semaglutide doesn’t work for everyone. There are many biological reasons why people struggle to lose weight. Found-affiliated clinicians, trained in obesity medicine, can help patients identify the root cause of their weight gain and personalize a prescription to target it. All prescriptions are written at a medical provider’s discretion.

More on personalized treatment with Found

How to use it

Compounded oral semaglutide dissolving tablets should be taken as prescribed by your health care provider. They are typically taken daily.

Place a tablet under the tongue or between the gum and cheek and let it dissolve—it takes about one minute. No water is needed. Don’t swallow the dissolving tablets. 

For best results, don’t eat or drink anything with calories or carbonation for 30 minutes after taking oral semaglutide dissolving tablets.

Dosing for compounded semaglutide is different from brand-name semaglutide. Follow your provider’s instructions for dosage.

Store compounded oral semaglutide dissolving tablets in the bottle they came in. Don’t use a pill organizer. Store them at room temperature in a dry place away from heat, light, and humidity. Do not keep them in the bathroom. 

Dosing

Dosing depends on your specific prescribed medication, your medical history, and your care provider’s instructions. Please read the insert that comes with your medicine.

Side effects

Commonly reported side effects of compounded semaglutide include:

  • Nausea and/or vomiting
  • Stomach pain
  • Diarrhea or constipation
  • Decreased appetite 

Black Box Warning

Compounded semaglutide oral dissolving tablets contain semaglutide, the active ingredient in brand name drugs like Ozempic, Wegovy, and Rybelsus.

The FDA warns not to take Ozempic, Wegovy, or Rybelsus if you have a personal or family history of medullary thyroid cancer or if you have multiple endocrine neoplasia syndrome type 2

Although rare, semaglutide caused thyroid C-cell tumors in animal studies. All brand-name GLP-1s with semaglutide as the active ingredient have a “black box” warning of the risk of these tumors. If you have trouble swallowing, develop hoarseness, or feel swelling or a lump in your neck, contact your health care provider immediately. 

Compounded semaglutide has warnings and side effects similar to brand-name products that list semaglutide as the active ingredient. 

Precautions

Rapid or significant weight loss can lead to excessive muscle loss. It’s important to start a strength training program and exercise regularly to protect your muscles while taking compounded semaglutide. 

Tell your health care provider if you have severe stomach problems that won’t go away, including abdominal bloating or pain, acid reflux, a feeling of fullness after eating just a few bites of food, nausea, and vomiting, including vomiting undigested food eaten a few hours earlier. These may be symptoms of gastroparesis (stomach paralysis). 

Use effective birth control while taking this medication. If you are pregnant, breastfeeding, or planning to become pregnant, do not take compounded semaglutide.

Compounded semaglutide isn’t appropriate for those with insulin-dependent diabetes or diabetic ketoacidosis. So, if that’s you, compounded semaglutide isn’t the right fit.

Interactions

Some drugs can also interact with semaglutide, including:

  • Insulin
  • Sulfonylureas (when combined, these can cause blood sugar levels to drop dangerously low) 
  • Some birth control pills
  • Other GLP-1 or GLP-1/GIP receptor agonist medications such as liraglutide, dulaglutide, or tirzepatide
  • Levothyroxine

Talk to your health care provider for more details about how this medicine might interact with other products and if you're taking any of these products.

Before taking this medication, talk to your health care provider if you have:

  • A history of pancreatitis
  • A history of kidney or liver problems

You should not drink alcohol while taking this drug because it can lower blood sugar. Combining alcohol with semaglutide may cause blood sugars to fall too fast, leading to fainting and dizziness.

If you are going under general anesthesia or deep sedation, GLP-1s may make you accidentally breathe food or liquid into your lungs (pulmonary aspiration).

Do not use this medication if you are, or suspect you may be, allergic to any of the ingredients in this compounded product.

about
found

Found is an online weight loss program offering personalized care for every member. Some of the nation’s top obesity medicine specialists helped design our program. Our approach is based on science, and we’re committed to clinical excellence.

Members get access to: Clinicians trained in obesity medicine 1:1 health coaching Self-paced lifestyle change program designed by doctors, psychologists, and behavioral scientists Exclusive in-app community.

Found’s comprehensive program is designed to work with your body—so you can achieve lasting results and enjoy better health.

*Found is not affiliated with Novo Nordisk A/S, the owner of the registered trademarks Rybelsus, Ozempic and Wegovy.

Alternative medications

Depending on your health history, weight history, and MetabolicPrintTM assessment, your Found health care provider may consider other alternatives to help you lose weight. Some are FDA-approved for weight loss. Others are used off-label and have strong clinical evidence supporting their use for weight loss.

Unfortunately, there are no generic versions of Ozempic currently on the market.
However, your health care provider might consider alternatives such as Wegovy, Mounjaro, or Saxenda, all of which are GLP-1 medications but not all are FDA-approved for weight loss specifically.

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