Terzepatide is contraindicated in individuals with a history of medullary thyroid carcinoma, a family history of such, or in patients with multiple endocrine neoplasia syndrome type 2. Do not take it if you have ever had thyroid cancer. In studies with rodents, tirzepatide caused thyroid tumors, including thyroid cancer; it is not known if it will cause thyroid tumors or cancer in humans. Please notify your doctor ASAP if you develop trouble swallowing, hoarseness, a lump or swelling in your neck, or shortness of breath.
If you experience a medical emergency, call 911 or go to the nearest emergency room.
Tell your health care provider about your medical history prior to taking Zepbound.
Avoid alcohol while taking this medication. If you’re taking diabetes medications, please discuss this with your prescribing doctor before starting Zepbound, as your diabetes medications may need to be adjusted as you lose weight.
People of childbearing age should use reliable birth control while taking this medication. Use a non-oral contraceptive method (instead of an oral contraceptive). If you use oral contraception, add a barrier method of contraception during the first four weeks after initiation and for four weeks after dose escalation.
This medication may cause fetal harm. Do not take this medication if pregnant, trying to get pregnant, or breastfeeding. If you plan to become pregnant, this medication needs to be stopped at least two months before trying. Notify your doctor if you have kidney, liver, or pancreas problems.
Stop using Zepbound and call your health care provider immediately if you have severe stomach or abdomen pain that will not go away, with or without vomiting.
Stop using Zepbound and get medical help right away if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue, or throat; problems breathing or swallowing; severe rash or itching; fainting or feeling dizzy; or a very rapid heartbeat.
Severe hypersensitivity reactions (e.g., anaphylaxis and angioedema) have been reported. Discontinue Zepbound if suspected and promptly seek medical advice.