How to use it
Novo Nordisk recommends injecting the once-a-day medicine under the skin in the upper arm, upper thigh, or stomach, rotating the injection site with each dose. Store the capped Saxenda pens in the refrigerator.
Dosing
For most patients, dosing typically begins with 0.6 mg each day for the first week. In the second week, daily injections increase to 1.2 mg. Daily doses increase to 1.8 mg in the third week, 2.4 mg in the fourth week, and 3 mg, the full dose, in the fifth and subsequent weeks of treatment. Make sure to let your health care provider know if you have any negative side effects as you increase the dose.
Side effects
Rapid or significant weight loss can lead to too much muscle loss. It’s important to start a strength training program and exercise regularly to protect your muscles while taking Saxenda.
Use effective birth control while taking this medication. If you are pregnant, breastfeeding, or planning to become pregnant, do not take Saxenda.Tell your health care provider if you have severe stomach problems that won’t go away, including abdominal bloating or pain, acid reflux, a feeling of fullness after eating just a few bites of food, nausea, and vomiting, including vomiting undigested food eaten a few hours earlier. These may be symptoms of gastroparesis (stomach paralysis).
Black Box Warning
Although rare, liraglutide caused thyroid C-cell tumors in animal studies. Saxenda’s “black box” warns of the risk of these tumors. If you have trouble swallowing, develop hoarseness, or feel swelling or a lump in your neck, contact your health care provider immediately.
The FDA also warns not to take Saxenda if you have a personal or family history of multiple endocrine neoplasia syndrome Type 2, medullary thyroid cancer, insulin-dependent diabetes, or diabetic ketoacidosis. So, if that’s you, Saxenda isn’t the right fit.
Precautions
Rapid or significant weight loss can lead to too much muscle loss. It’s important to start a strength training program and exercise regularly to protect your muscles while taking Saxenda.
Use effective birth control while taking this medication. If you are pregnant, breastfeeding, or planning to become pregnant, do not take Saxenda.Tell your health care provider if you have severe stomach problems that won’t go away, including abdominal bloating or pain, acid reflux, a feeling of fullness after eating just a few bites of food, nausea, and vomiting, including vomiting undigested food eaten a few hours earlier. These may be symptoms of gastroparesis (stomach paralysis).
Interactions
Some drugs can also interact with Saxenda, including:
- Insulin
- Sulfonylureas (these can cause blood sugar levels to drop dangerously low when combined with Saxenda )
- Some birth control pills
- Other GLP-1 or GLP-1/GIP receptor agonist medications such as dulaglutide, semaglutide, or tirzepatide
You should not drink alcohol while taking this drug because alcohol can lower blood sugar. Combining alcohol with this medication may cause blood sugars to fall too fast, leading to fainting and dizziness.