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Rybelsus® can mimic the glucagon-like peptide-1 (GLP-1) hormone, which plays a role in digestion and appetite regulation, causing you to feel fuller faster.

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Medication name


Conditions FDA-approved to treat

Type 2 Diabetes

Benefits for weight loss

Regulate insulin

Balance blood sugar

Reduce appetite

Everything you need to know

  • How it works

    This medication is part of a class of medications called Glucagon like peptide-1 (GLP-1s) which can help you feel fuller and helps to stabilize blood sugar levels. They can also help with cravings and appetite and have been found to be very effective for weight loss. Rybelsus® is FDA-approved for the treatment of type 2 diabetes.

  • Form and dosing

    Rybelsus® comes in a tablet form at dosages starting at 3 mg. The tablet must be kept in the bottle until it is ready to be taken and the tablet should be swallowed whole. A pill organizer or other container should not be used to store Rybelsus® tablets. All tablets should be kept in the bottle with the cap on and stored at room temperature in a dry place. It should be taken with a sip of water (less than 4 ounces), 30 min before food/drink/medication, it should not be cut, crushed or chewed or exposed to air. Dosing instructions vary according to weight, tolerability and other factors and should be discussed with your healthcare provider.

  • Common side effects

    Nausea, vomiting, constipation, and diarrhea

What are doctors saying?

Rybelsus® is also used together with diet and exercise to help lose weight and keep the weight off in patients with obesity caused by certain conditions.

— Mayo Clinic

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Here’s a closer look, plus answers to all your questions with Dr. Rekha Kumar:

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Still have questions?

Visit our FAQs or reach out to your clinical team.

Medical Disclaimers

Rybelsus® is only FDA-approved to treat type 2 diabetes. Medication prescriptions are up to a medical provider’s discretion and may not be appropriate for everyone.

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Rybelsus® warnings


GLP-1s are contraindicated in individuals with a history of medullary thyroid carcinoma, a family history of such, or in patients with multiple endocrine neoplasia syndrome type 2. Do not take them if you have ever had thyroid cancer. In studies with rodents, GLP-1s caused thyroid tumors, including thyroid cancer; it is not known if they will cause thyroid tumors or cancer in humans. Please notify your doctor ASAP if you develop trouble swallowing, hoarseness, a lump or swelling in your neck, or shortness of breath. 

If you experience a medical emergency, call 911 or go to the nearest emergency room.

Tell your healthcare provider about your medical history prior to taking Rybelsus.

Avoid alcohol while taking this medication. If you’re taking diabetes medications, please discuss this with your prescribing doctor before starting Rybelsus, as your diabetes medications may need to be adjusted as you lose weight.

Use adequate contraception while taking this medication. Do not take this medication if pregnant, trying to get pregnant or breastfeeding. If you plan to become pregnant, this medication needs to be stopped at least 2 months before trying. This medication may cause fetal harm.

Notify your doctor if you have kidney, liver, or pancreas problems.

Stop using Rybelsus and call your healthcare provider immediately if you have severe stomach or abdomen pain that will not go away, with or without vomiting.

Stop using Rybelsus and get medical help right away if you have any symptoms of a serious allergic reaction, including swelling of your face, lips, tongue, or throat; problems breathing or swallowing; severe rash or itching; fainting or feeling dizzy; or very rapid heartbeat.

Serious hypersensitivity reactions (e.g., anaphylaxis and angioedema) have been reported. Discontinue Rybelsus if suspected and promptly seek medical advice.


Please contact your doctor ASAP and seek in-person care immediately if a side effect becomes problematic or you experience:

  • Severe nausea and/or vomiting resulting in dehydration-  it is important to stay well hydrated and drink plenty of fluids while on this medication 
  • Kidney problems/kidney failure - vomiting, nausea, diarrhea can cause dehydration and kidney issues and make kidney problems worse in individuals who have pre-existing kidney conditions; may sometimes lead to the need for hemodialysis 
  • Thyroid C-Cell Tumor: Trouble swallowing, hoarseness, a lump or swelling in your neck, or shortness of breath (see black box warning below)
  • Pancreatitis: Severe pain in your abdomen or back that will not go away 
  • Acute gallbladder disease - Pain in the middle or right upper stomach, fever, white parts of your eyes turn yellow or skin turns yellow, nausea/vomiting. if gallstones or inflammation of the gallbladder is suspected further studies are needed.
  • Hepatitis/Elevated liver enzymes/Jaundice
  • Diabetic retinopathy problems: Changes in vision in those with type II diabetes, particularly vision problems may worsen in those with a history of diabetic retinopathy 
  • Severe gastrointestinal disease - may cause gastrointestinal disease; do not use if you have a history of severe gastrointestinal disease 
  • Signs of low blood sugar (for example, dizziness, weakness, shakiness, jitteriness, headache, anxiety/mood changes, rapid heartbeat, confusion, slurred speech, sweating, or lightheadedness). While this is rare with GLP-1s, if it occurs, please seek in-person care immediately. If you have these symptoms, try having liquid or food containing sugar (around 15-20 grams) —drinking juice, having regular soda, or eating some hard candies right away, as this will help raise your blood sugar quickly. If taken with insulin or an insulin secretagogue (ie sulfonylurea) it is best to talk to your healthcare provider about possibly lowering the dose of these medications to lower the risk of hypoglycemia. 
  • Increasing heart rate
  • Worsening depression, behavior changes, or suicidality

Side effects information

Many people experience no side effects. Some of the most common or potential side effects include:

  • Nausea
  • Constipation
  • Vomiting
  • Diarrhea
  • Abdominal Pain
  • Headache
  • Indigestion 
  • Dizziness
  • Back pain
  • Increased Lipase or Amylase 
  • Altered taste
  • Nasopharyngitis (common cold)
  • Passing Gas
  • Bloating
  • Belching
  • Gastroenteritis
  • Decreased appetite 
  • Fatigue
  • Gastroesophageal reflux disease
  • Low blood sugar (hypoglycemia) in those with type II diabetes
  • Upset stomach

These symptoms often subside as your body adjusts to the medications. Please notify your provider if side effects persist. For a complete list of side effects, review the medication packaging inserts.

Drug interactions

As with other medications, Rybelsus can interact with alcohol and certain prescription and non-prescription medications and herbal products. The risk of hypoglycemia is increased when combined with insulin or insulin secretagogues such as sulfonylureas. Rybelsus delays gastric emptying and may impact the absorption of oral medications. If you are on thyroid hormone medication, prior to starting Rybelsus, please review the timing of taking your thyroid hormone medication with the doctor who prescribes it as it may need to be adjusted. The drug levels of medications with narrow therapeutic windows (ie warfarin) should be monitored closely while on Rybelsus.

Please consult the pharmaceutical packaging for a full list of side effects, warnings, interactions and additional information. 

To report suspected adverse reactions to Rybelsus contact the FDA at 1-800-FDA-1088 or

In case of emergencies, please call 911 or go to the nearest emergency room.